Halofuginone inhibits TGF-β/BMP signaling and in combination with zoledronic acid enhances inhibition of breast cancer bone metastasis

More efficient therapies that target multiple molecular mechanisms are needed for the treatment of incurable bone metastases. Halofuginone is a plant alkaloid-derivative with antiangiogenic and antiproliferative effects. Here we demonstrate that halofuginone is an effective therapy for the treatment...

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Publicado en:Oncotarget
Autores principales: Juárez, Patricia, Fournier, Pierrick G.J., Mohammad, Khalid S., McKenna, Ryan C., Davis, Holly W., Peng, Xiang H., Niewolna, Maria, Mauviel, Alain, Chirgwin, John M., Guise, Theresa A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689697/
https://ncbi.nlm.nih.gov/pubmed/29156807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21200
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