Halofuginone inhibits TGF-β/BMP signaling and in combination with zoledronic acid enhances inhibition of breast cancer bone metastasis

More efficient therapies that target multiple molecular mechanisms are needed for the treatment of incurable bone metastases. Halofuginone is a plant alkaloid-derivative with antiangiogenic and antiproliferative effects. Here we demonstrate that halofuginone is an effective therapy for the treatment...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Juárez, Patricia, Fournier, Pierrick G.J., Mohammad, Khalid S., McKenna, Ryan C., Davis, Holly W., Peng, Xiang H., Niewolna, Maria, Mauviel, Alain, Chirgwin, John M., Guise, Theresa A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689697/
https://ncbi.nlm.nih.gov/pubmed/29156807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21200
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