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Modulation of HIF-1α and STAT3 signaling contributes to anti-angiogenic effect of YC-1 in mice with liver fibrosis

Hypoxia has been shown to have a role in the pathogenesis of several forms of liver disease. The aim of the study was to evaluate the mechanisms of HIF-1α inhibitor, YC-1, during bile duct ligation (BDL)-induced liver fibrosis in mice. Liver fibrosis was induced in mice, and YC-1 was then given intr...

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Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Lee, Tzung-Yan, Leu, Yann-Lii, Wen, Chorng-Kai
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689678/
https://ncbi.nlm.nih.gov/pubmed/29156788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21039
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