Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells

BACKGROUND: Hepatocellular carcinoma (HCC) growth relies on angiogenesis via vascular endothelial growth factor (VEGF) release. Hypoxia within tumour environment leads to intracellular stabilisation of hypoxia inducible factor 1 alpha (Hif1α) and signal transducer and activator of transcription (STA...

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Détails bibliographiques
Auteurs principaux: Carbajo-Pescador, S, Ordoñez, R, Benet, M, Jover, R, García-Palomo, A, Mauriz, J L, González-Gallego, J
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2013
Sujets:
Translational Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708553/
https://ncbi.nlm.nih.gov/pubmed/23756865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.285
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