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HIF-1α activation mediates resistance to anti-angiogenic therapy in neuroblastoma xenografts
INTRODUCTION: The anti-tumor activity of angiogenesis inhibitors is often limited by the development of resistance to these drugs. Here we establish HIF-1α as a major factor in the development of this resistance in neuroblastoma xenografts. METHODS: Neuroblastoma xenografts were established by injec...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3601778/ https://ncbi.nlm.nih.gov/pubmed/23331791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpedsurg.2012.10.016 |
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