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HIF-1α activation mediates resistance to anti-angiogenic therapy in neuroblastoma xenografts

INTRODUCTION: The anti-tumor activity of angiogenesis inhibitors is often limited by the development of resistance to these drugs. Here we establish HIF-1α as a major factor in the development of this resistance in neuroblastoma xenografts. METHODS: Neuroblastoma xenografts were established by injec...

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Bibliographische Detailangaben
Hauptverfasser: Hartwich, Joseph, Orr, W. Shannon, Ng, Catherine Y., Spence, Yunyu, Morton, Christopher, Davidoff, Andrew M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601778/
https://ncbi.nlm.nih.gov/pubmed/23331791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpedsurg.2012.10.016
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