Induction of DISE in ovarian cancer cells in vivo

The death receptor CD95/Fas can be activated by immune cells to kill cancer cells. shRNAs and siRNAs derived from CD95 or CD95 ligand (CD95L) are highly toxic to most cancer cells. We recently found that these sh/siRNAs kill cancer cells in the absence of the target by targeting the 3’UTRs of critic...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Murmann, Andrea E., McMahon, Kaylin M., Haluck-Kangas, Ashley, Ravindran, Nandini, Patel, Monal, Law, Calvin Y., Brockway, Sonia, Wei, Jian-Jun, Thaxton, C. Shad, Peter, Marcus E.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689563/
https://ncbi.nlm.nih.gov/pubmed/29156673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21471
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