Revealing the Determinants of Widespread Alternative Splicing Perturbation in Cancer

It is increasingly appreciated that alternative splicing plays a key role in generating functional specificity and diversity in cancer. However, the mechanisms by which cancer mutations perturb splicing remain unknown. Here, we developed a network-based strategy, DrAS-Net, to investigate over 2.5 mi...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Li, Yongsheng, Sahni, Nidhi, Pancsa, Rita, McGrail, Daniel J., Xu, Juan, Hua, Xu, Coulombe-Huntington, Jasmin, Ryan, Michael, Tychhon, Boranai, Sudhakar, Dhanistha, Hu, Limei, Tyers, Michael, Jiang, Xiaoqian, Lin, Shiaw-Yih, Babu, M. Madan, Yi, Song
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689467/
https://ncbi.nlm.nih.gov/pubmed/29045845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.071
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