PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain

AMP-activated protein kinase (AMPK) occurs as heterotrimeric complexes in which a catalytic subunit (α1/α2) is bound to one of two β subunits (β1/β2) and one of three γ subunits (γ1/γ2/γ3). The ability to selectively activate specific isoforms would be a useful research tool, and a promising strateg...

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Publicado en:Biochem J
Autores principales: Jensen, Thomas E., Ross, Fiona A., Kleinert, Maximilian, Sylow, Lykke, Knudsen, Jonas R., Hardie, D. Grahame, Richter, Erik A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689378/
https://ncbi.nlm.nih.gov/pubmed/25695398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20141142
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