Cancer cell-soluble factors reprogram mesenchymal stromal cells to slow cycling, chemoresistant cells with a more stem-like state

BACKGROUND: Mesenchymal stem cells (MSCs) play different roles in modulating tumor progression, growth, and metastasis. MSCs are recruited to the tumor site in large numbers and subsequently have an important microenvironmental role in modulating tumor progression and drug sensitivity. However, the...

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Veröffentlicht in:Stem Cell Res Ther
Hauptverfasser: El-Badawy, Ahmed, Ghoneim, Mohamed A., Gabr, Mahmoud M., Salah, Radwa Ayman, Mohamed, Ihab K., Amer, Marwa, El-Badri, Nagwa
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5688803/
https://ncbi.nlm.nih.gov/pubmed/29115987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-017-0709-9
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