Mitochondrial Calcium Dysregulation Contributes to Dendrite Degeneration Mediated by PD/LBD-Associated LRRK2 Mutants

Mutations in leucine-rich repeat kinase 2 (LRRK2) contribute to development of late-onset familial Parkinson's disease (PD), with clinical features of motor and cognitive dysfunction indistinguishable from sporadic PD. Calcium dysregulation plays an important role in PD pathogenesis, but the me...

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Detalhes bibliográficos
Publicado no:J Neurosci
Principais autores: Verma, Manish, Callio, Jason, Otero, P. Anthony, Sekler, Israel, Wills, Zachary P., Chu, Charleen T.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5688524/
https://ncbi.nlm.nih.gov/pubmed/29038245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3791-16.2017
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