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Mutant LRRK2 Enhances Glutamatergic Synapse Activity and Evokes Excitotoxic Dendrite Degeneration
Mutations in leucine rich repeat kinase 2 (LRRK2), which are associated with autosomal dominant Parkinson’s disease, elicit progressive dendrite degeneration in neurons. We hypothesized that synaptic dysregulation contributes to mutant LRRK2-induced dendritic injury. We performed in vitro whole-cell...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4144018/ https://ncbi.nlm.nih.gov/pubmed/24874075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2014.05.016 |
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