Mutant LRRK2 Enhances Glutamatergic Synapse Activity and Evokes Excitotoxic Dendrite Degeneration

Mutations in leucine rich repeat kinase 2 (LRRK2), which are associated with autosomal dominant Parkinson’s disease, elicit progressive dendrite degeneration in neurons. We hypothesized that synaptic dysregulation contributes to mutant LRRK2-induced dendritic injury. We performed in vitro whole-cell...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Plowey, Edward D., Johnson, Jon W., Steer, Erin, Zhu, Wan, Eisenberg, David A., Valentino, Natalie M., Liu, Yong-Jian, Chu, Charleen T.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144018/
https://ncbi.nlm.nih.gov/pubmed/24874075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2014.05.016
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares