PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer

PTEN activity is often lost in prostate cancer. We show that the tyrosine kinase PTK6 (BRK) is a PTEN substrate. Phosphorylation of PTK6 tyrosine 342 (PY342) promotes activation, while phosphorylation of tyrosine 447 (PY447) regulates auto-inhibition. Introduction of PTEN into a PTEN null prostate c...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Wozniak, Darren J., Kajdacsy-Balla, Andre, Macias, Virgilia, Ball-Kell, Susan, Zenner, Morgan L., Bie, Wenjun, Tyner, Angela L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5688148/
https://ncbi.nlm.nih.gov/pubmed/29142193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01574-5
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