PTK6 activation at the membrane regulates epithelial-mesenchymal transition in prostate cancer

The intracellular tyrosine kinase PTK6 lacks a membrane-targeting SH4 domain and localizes to the nuclei of normal prostate epithelial cells. However, PTK6 translocates from the nucleus to the cytoplasm in human prostate tumor cells. Here we show that while PTK6 is located primarily within the cytop...

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Detalhes bibliográficos
Main Authors: Zheng, Yu, Wang, Zebin, Bie, Wenjun, Brauer, Patrick M., White, Bethany E. Perez, Li, Jing, Nogueira, Veronique, Raychaudhuri, Pradip, Hay, Nissim, Tonetti, Debra A., Macias, Virgilia, Kajdacsy-Balla, André, Tyner, Angela L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3766391/
https://ncbi.nlm.nih.gov/pubmed/23856248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-0443
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