Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma

The Fbxo4 tumour suppressor is a component of an Skp1-Cul1-F-box E3 ligase for which two substrates are known. Here we show purification of SCF(Fbxo4) complexes results in the identification of fragile X protein family (FMRP, Fxr1 and Fxr2) as binding partners. Biochemical and functional analyses re...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Qie, Shuo, Majumder, Mrinmoyee, Mackiewicz, Katarzyna, Howley, Breege V., Peterson, Yuri K., Howe, Philip H., Palanisamy, Viswanathan, Diehl, J. Alan
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5688124/
https://ncbi.nlm.nih.gov/pubmed/29142209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01199-8
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