A Nonredundant Role for the TRPM6 Channel in Neural Tube Closure

In humans, germline mutations in Trpm6 cause autosomal dominant hypomagnesemia with secondary hypocalcemia disorder. Loss of Trpm6 in mice also perturbs cellular magnesium homeostasis but additionally results in early embryonic lethality and neural tube closure defects. To define the mechanisms by w...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Komiya, Yuko, Bai, Zhiyong, Cai, Na, Lou, Liping, Al-Saadi, Namariq, Mezzacappa, Courtney, Habas, Raymond, Runnels, Loren W.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5688082/
https://ncbi.nlm.nih.gov/pubmed/29142255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15855-y
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