Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis

Coronaviruses (CoVs) encode a mixture of highly conserved and novel genes, as well as genetic elements necessary for infection and pathogenesis, raising the possibility of common targets for attenuation and therapeutic design. In this study, we focused on highly conserved nonstructural protein 16 (N...

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Vydáno v:mSphere
Hlavní autoři: Menachery, Vineet D., Gralinski, Lisa E., Mitchell, Hugh D., Dinnon, Kenneth H., Leist, Sarah R., Yount, Boyd L., Graham, Rachel L., McAnarney, Eileen T., Stratton, Kelly G., Cockrell, Adam S., Debbink, Kari, Sims, Amy C., Waters, Katrina M., Baric, Ralph S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687918/
https://ncbi.nlm.nih.gov/pubmed/29152578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00346-17
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