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Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling
Insulin resistance is a hallmark of diabetes and an unmet clinical need. Insulin inhibits hepatic glucose production and promotes lipogenesis by suppressing FOXO1-dependent activation of G6pase and inhibition of Glucokinase, respectively. The tight coupling of these events poses a dual conundrum: me...
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| Publicado en: | Cell |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5687849/ https://ncbi.nlm.nih.gov/pubmed/29056338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.045 |
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