Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling

Insulin resistance is a hallmark of diabetes and an unmet clinical need. Insulin inhibits hepatic glucose production and promotes lipogenesis by suppressing FOXO1-dependent activation of G6pase and inhibition of Glucokinase, respectively. The tight coupling of these events poses a dual conundrum: me...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell
Päätekijät: Langlet, Fanny, Haeusler, Rebecca A., Lindén, Daniel, Ericson, Elke, Norris, Tyrrell, Johansson, Anders, Cook, Joshua R., Aizawa, Kumiko, Wang, Ling, Buettner, Christoph, Accili, Domenico
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687849/
https://ncbi.nlm.nih.gov/pubmed/29056338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.045
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