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DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death

Influenza A virus (IAV) is an RNA virus that is cytotoxic to most cell types in which it replicates. IAV activates the host kinase RIPK3, which induces cell death via parallel pathways of necroptosis, driven by the pseudokinase MLKL, and apoptosis, dependent on the adaptor proteins RIPK1 and FADD. H...

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Foilsithe in:Cell Host Microbe
Main Authors: Thapa, Roshan J., Ingram, Justin P., Ragan, Katherine B., Nogusa, Shoko, Boyd, David F., Benitez, Asiel A., Sridharan, Haripriya, Kosoff, Rachelle, Shubina, Maria, Landsteiner, Vanessa J., Andrake, Mark, Vogel, Peter, Sigal, Luis J., tenOever, Benjamin R., Thomas, Paul G., Upton, Jason W., Balachandran, Siddharth
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687825/
https://ncbi.nlm.nih.gov/pubmed/27746097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2016.09.014
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