DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death

Influenza A virus (IAV) is an RNA virus that is cytotoxic to most cell types in which it replicates. IAV activates the host kinase RIPK3, which induces cell death via parallel pathways of necroptosis, driven by the pseudokinase MLKL, and apoptosis, dependent on the adaptor proteins RIPK1 and FADD. H...

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Vydáno v:Cell Host Microbe
Hlavní autoři: Thapa, Roshan J., Ingram, Justin P., Ragan, Katherine B., Nogusa, Shoko, Boyd, David F., Benitez, Asiel A., Sridharan, Haripriya, Kosoff, Rachelle, Shubina, Maria, Landsteiner, Vanessa J., Andrake, Mark, Vogel, Peter, Sigal, Luis J., tenOever, Benjamin R., Thomas, Paul G., Upton, Jason W., Balachandran, Siddharth
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687825/
https://ncbi.nlm.nih.gov/pubmed/27746097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2016.09.014
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