Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1

UDP-glucuronosyltransferase 1A1 (UGT1A1) plays a key role in detoxification of many potentially harmful compounds and drugs. UGT1A1 inhibition may bring risks of drug–drug interactions (DDIs), hyperbilirubinemia and drug-induced liver injury. This study aimed to investigate and compare the inhibitor...

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Detalhes bibliográficos
Publicado no:Acta Pharm Sin B
Main Authors: Cheng, Xuewei, Lv, Xia, Qu, Hengyan, Li, Dandan, Hu, Mengmeng, Guo, Wenzhi, Ge, Guangbo, Dong, Ruihua
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687316/
https://ncbi.nlm.nih.gov/pubmed/29159025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2017.07.004
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