Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells

Autophagy is required for benign hepatic tumors to progress into malignant hepatocellular carcinoma. However, the mechanism is unclear. Here we report that mitophagy, the selective removal of mitochondria by autophagy, positively regulates hepatic cancer stem cells (CSCs) by suppressing the tumor su...

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I publikationen:Mol Cell
Huvudupphovsmän: Liu, Kai, Lee, Jiyoung, Kim, Ja Yeon, Wang, Linya, Tian, Yongjun, Chan, Stephanie T., Cho, Cecilia, Machida, Keigo, Chen, Dexi, Ou, Jing-Hsiung James
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687282/
https://ncbi.nlm.nih.gov/pubmed/29033320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.09.022
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