TNF-α Induced by Hepatitis C Virus via TLR7 and TLR8 in Hepatocytes Supports Interferon Signaling via an Autocrine Mechanism

Invasion by infectious pathogens can elicit a range of cytokine responses from host cells. These cytokines provide the initial host defense mechanism. In this report, we demonstrate that TNF-α, a pro-inflammatory cytokine, can be induced by hepatitis C virus (HCV) in its host cells in a biphasic man...

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Bibliografiska uppgifter
I publikationen:PLoS Pathog
Huvudupphovsmän: Lee, Jiyoung, Tian, Yongjun, Chan, Stephanie Tze, Kim, Ja Yeon, Cho, Cecilia, Ou, Jing-hsiung James
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2015
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449221/
https://ncbi.nlm.nih.gov/pubmed/26023919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004937
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