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The E3 Ligase CHIP Mediates p21 Degradation to Maintain Radioresistance
Lung cancer resists radiation therapy, making it one of the deadliest forms of cancer. Here we show that human lung cancer cell lines can be rendered sensitive to ionizing radiation (IR) by RNAi knockdown of C-terminus of Hsc70-interacting protein (CHIP/STUB1), a U-box-type E3 ubiquitin ligase that...
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| Publicado no: | Mol Cancer Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5687089/ https://ncbi.nlm.nih.gov/pubmed/28232384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-16-0466 |
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