Differential Inhibitory Receptor Expression on T Cells Delineates Functional Capacities in Chronic Viral Infection

Inhibitory receptors have been extensively described for their importance in regulating immune responses in chronic infections and cancers. Blocking the function of inhibitory receptors such as PD-1, CTLA-4, 2B4, Tim-3, and LAG-3 has shown promise for augmenting CD8 T cell activity and boosting path...

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Veröffentlicht in:J Virol
Hauptverfasser: Teigler, Jeffrey E., Zelinskyy, Gennadiy, Eller, Michael A., Bolton, Diane L., Marovich, Mary, Gordon, Alexander D., Alrubayyi, Aljawharah, Alter, Galit, Robb, Merlin L., Martin, Jeffrey N., Deeks, Steven G., Michael, Nelson L., Dittmer, Ulf, Streeck, Hendrik
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5686724/
https://ncbi.nlm.nih.gov/pubmed/28904197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01263-17
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