Aldosterone-Producing Cell Clusters Frequently Harbor Somatic Mutations and Accumulate With Age in Normal Adrenals

CONTEXT: Aldosterone synthase (CYP11B2) immunohistochemistry and next-generation sequencing (NGS) have revealed the frequent presence of aldosterone-producing cell clusters (APCCs) harboring somatic mutations in aldosterone-regulating genes in adrenals from Americans without defined hypertension sta...

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Dades bibliogràfiques
Publicat a:J Endocr Soc
Autors principals: Omata, Kei, Anand, Sharath K., Hovelson, Daniel H., Liu, Chia-Jen, Yamazaki, Yuto, Nakamura, Yasuhiro, Ito, Sadayoshi, Satoh, Fumitoshi, Sasano, Hironobu, Rainey, William E., Tomlins, Scott A.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2017
Matèries:
Clinical Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5686701/
https://ncbi.nlm.nih.gov/pubmed/29264530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2017-00134
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