Intranasal Lactoferrin Enhances α-Secretase-Dependent Amyloid Precursor Protein Processing via the ERK1/2-CREB and HIF-1α Pathways in an Alzheimer’s Disease Mouse Model

Growing evidence suggests that lactoferrin (Lf), an iron-binding glycoprotein, is a pleiotropic functional nutrient. In addition, Lf was recently implicated as a neuroprotective agent. These properties make Lf a valuable therapeutic candidate for the treatment of Alzheimer’s disease (AD). However, t...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Guo, Chuang, Yang, Zhao-Hui, Zhang, Shuai, Chai, Rui, Xue, Han, Zhang, Yan-Hui, Li, Jia-Yi, Wang, Zhan-You
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5686501/
https://ncbi.nlm.nih.gov/pubmed/28079060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2017.8
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