Predictors of Naltrexone Response in a Randomized Trial: Reward-Related Brain Activation, OPRM1 Genotype, and Smoking Status

Naltrexone reduces drinking among individuals with alcohol use disorders (AUDs), but it is not effective for everyone. Variability in its effects on reward-related brain activation, genetic variation, and/or cigarette smoking may account for this mixed response profile. This randomized clinical tria...

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Veröffentlicht in:Neuropsychopharmacology
Hauptverfasser: Schacht, Joseph P, Randall, Patrick K, Latham, Patricia K, Voronin, Konstantin E, Book, Sarah W, Myrick, Hugh, Anton, Raymond F
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5686497/
https://ncbi.nlm.nih.gov/pubmed/28409564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2017.74
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