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Aurora kinase A inhibitor TCS7010 demonstrates pro-apoptotic effect through the unfolded protein response pathway in HCT116 colon cancer cells

Aurora kinase A (AURKA) is essential for regulating mitosis and is frequently amplified in various cancer cell types. However, the effect of AURKA inhibition on the induction of apoptosis remains unclear. In the present study, it was reported that treatment with TCS7010, a specific inhibitor of AURK...

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Detalhes bibliográficos
Publicado no:Oncol Lett
Main Authors: Lee, Da Hyun, Kim, Chang Gun, Lim, Yoongho, Shin, Soon Young
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5686436/
https://ncbi.nlm.nih.gov/pubmed/29163689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2017.7023
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