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Inhibitory Effect of Synthetic Flavone Derivatives on Pan-Aurora Kinases: Induction of G2/M Cell-Cycle Arrest and Apoptosis in HCT116 Human Colon Cancer Cells

Members of the aurora kinase family are Ser/Thr kinases involved in regulating mitosis. Multiple promising clinical trials to target aurora kinases are in development. To discover flavones showing growth inhibitory effects on cancer cells, 36 flavone derivatives were prepared, and their cytotoxicity...

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Main Authors: Soon Young Shin, Youngshim Lee, Beom Soo Kim, Junho Lee, Seunghyun Ahn, Dongsoo Koh, Yoongho Lim, Young Han Lee
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2018-12-01
Colecção:International Journal of Molecular Sciences
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Acesso em linha:https://www.mdpi.com/1422-0067/19/12/4086
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