Inhibitory Effect of Synthetic Flavone Derivatives on Pan-Aurora Kinases: Induction of G2/M Cell-Cycle Arrest and Apoptosis in HCT116 Human Colon Cancer Cells

Members of the aurora kinase family are Ser/Thr kinases involved in regulating mitosis. Multiple promising clinical trials to target aurora kinases are in development. To discover flavones showing growth inhibitory effects on cancer cells, 36 flavone derivatives were prepared, and their cytotoxicity...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Soon Young Shin, Youngshim Lee, Beom Soo Kim, Junho Lee, Seunghyun Ahn, Dongsoo Koh, Yoongho Lim, Young Han Lee
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: MDPI AG 2018-12-01
Σειρά:International Journal of Molecular Sciences
Θέματα:
flavones
colon cancer
clonogenicity
apoptosis
aurora kinases
quantitative structure–activity relationship
in-silico docking
Διαθέσιμο Online:https://www.mdpi.com/1422-0067/19/12/4086
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