Inhibitory Effect of Synthetic Flavone Derivatives on Pan-Aurora Kinases: Induction of G2/M Cell-Cycle Arrest and Apoptosis in HCT116 Human Colon Cancer Cells

Members of the aurora kinase family are Ser/Thr kinases involved in regulating mitosis. Multiple promising clinical trials to target aurora kinases are in development. To discover flavones showing growth inhibitory effects on cancer cells, 36 flavone derivatives were prepared, and their cytotoxicity...

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Bibliographic Details
Main Authors: Soon Young Shin, Youngshim Lee, Beom Soo Kim, Junho Lee, Seunghyun Ahn, Dongsoo Koh, Yoongho Lim, Young Han Lee
Format: Artigo
Language:Inglês
Published: MDPI AG 2018-12-01
Series:International Journal of Molecular Sciences
Subjects:
flavones
colon cancer
clonogenicity
apoptosis
aurora kinases
quantitative structure–activity relationship
in-silico docking
Online Access:https://www.mdpi.com/1422-0067/19/12/4086
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