iRAGu: A Novel Inducible and Reversible Mouse Model for Ubiquitous Recombinase Activity

Developing lymphocytes express the recombination activating genes (RAGs) 1 and 2 products that form a site specific recombinase complex (RAG), introducing double strand DNA breaks (DSBs) at recombination signal sequences (RSSs) flanking the V, D, and J gene segments in the antigen receptor loci. The...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Bonnet, Marie, Sarmento, Leonor Morais, Martins, Ana C., Sobral, Daniel, Silva, Joana, Demengeot, Jocelyne
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5686385/
https://ncbi.nlm.nih.gov/pubmed/29176980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01525
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