Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys

Kidney injury initiates metabolic reprogramming in tubule cells that contributes to the development of chronic kidney disease (CKD). Exercise has been associated with beneficial effects in patients with CKD. Here we show that the induction of a myokine, irisin, improves kidney energy metabolism and...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Peng, Hui, Wang, Qianqian, Lou, Tanqi, Qin, Jun, Jung, Sungyun, Shetty, Vivekananda, Li, Feng, Wang, Yanlin, Feng, Xin-hua, Mitch, William E., Graham, Brett H., Hu, Zhaoyong
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5686208/
https://ncbi.nlm.nih.gov/pubmed/29138395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01646-6
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