Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys

Kidney injury initiates metabolic reprogramming in tubule cells that contributes to the development of chronic kidney disease (CKD). Exercise has been associated with beneficial effects in patients with CKD. Here we show that the induction of a myokine, irisin, improves kidney energy metabolism and...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Peng, Hui, Wang, Qianqian, Lou, Tanqi, Qin, Jun, Jung, Sungyun, Shetty, Vivekananda, Li, Feng, Wang, Yanlin, Feng, Xin-hua, Mitch, William E., Graham, Brett H., Hu, Zhaoyong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5686208/
https://ncbi.nlm.nih.gov/pubmed/29138395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01646-6
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