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Phosphoinositide 3-kinase γ deficiency attenuates kidney injury and fibrosis in angiotensin II–induced hypertension

BACKGROUND: We have shown that the CXCL16/CXCR6 axis plays a critical role in recruiting inflammatory cells and bone marrow-derived fibroblasts into the kidney leading to renal injury and fibrosis. However, the underlying signaling mechanisms are not known. METHODS: In the present study, we examined...

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Detalhes bibliográficos
Publicado no:Nephrol Dial Transplant
Main Authors: An, Changlong, Wen, Jia, Hu, Zhaoyong, Mitch, William E, Wang, Yanlin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7778344/
https://ncbi.nlm.nih.gov/pubmed/32500132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ndt/gfaa062
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