Structure-function relationships in ABCG2: insights from molecular dynamics simulations and molecular docking studies

Efflux pumps of the ATP-binding cassette transporters superfamily (ABC transporters) are frequently involved in the multidrug-resistance (MDR) phenomenon in cancer cells. Herein, we describe a new atomistic model for the MDR-related ABCG2 efflux pump, also named breast cancer resistance protein (BCR...

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Vydáno v:Sci Rep
Hlavní autoři: Ferreira, Ricardo J., Bonito, Cátia A., Cordeiro, M. Natália D. S., Ferreira, Maria-José U., dos Santos, Daniel J. V. A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5686161/
https://ncbi.nlm.nih.gov/pubmed/29138424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15452-z
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