The antigenic variability of HCV in viral HLA-Ag binding is related to the activation of the host immune response

Our previous data show that hepatitis C virus (HCV) genotype 1 patients expressing the HLA-DQB1 * 0301 allele have a combined response probability of 69%, while the remaining 31% do not respond, probably because the HCV immunodominant epitope (IE) against the DQB1 * 0301 allele is mutated. HCV IE (r...

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Pubblicato in:Sci Rep
Autori principali: Muñoz de Rueda, P., Jiménez-Ruiz, S. M., Quiles, R., Pavón-Castillero, E. J., Muñoz-Gámez, J. A., Casado, J., Gila, A., Ruiz-Extremera, A., Salmerón, J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5686107/
https://ncbi.nlm.nih.gov/pubmed/29138492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15605-0
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