Mutations in E2-PePHD, NS5A-PKRBD, NS5A-ISDR, and NS5A-V3 of Hepatitis C Virus Genotype 1 and Their Relationships to Pegylated Interferon-Ribavirin Treatment Responses

Mutations in several subgenomic regions of hepatitis C virus (HCV) have been implicated in influencing the response to interferon (IFN) therapy. Sequences within HCV NS5A (PKR binding domain [PKRBD], IFN sensitivity-determining region [ISDR], and variable region 3 [V3]) were analyzed for the pretrea...

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Autors principals: de Rueda, P. Muñoz, Casado, J., Patón, R., Quintero, D., Palacios, A., Gila, A., Quiles, R., León, J., Ruiz-Extremera, A., Salmerón, J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447059/
https://ncbi.nlm.nih.gov/pubmed/18448540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02231-07
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