Macitentan, a double antagonist of endothelin receptors, efficiently impairs migration and microenvironmental survival signals in chronic lymphocytic leukemia

The crosstalk between chronic lymphocytic leukemia (CLL) cells and tumor microenvironment is essential for leukemic clone maintenance, supporting CLL cells survival, proliferation and protection from drug-induced apoptosis. Over the past years, the role of several soluble factors involved in these p...

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Udgivet i:Oncotarget
Main Authors: Maffei, Rossana, Fiorcari, Stefania, Vaisitti, Tiziana, Martinelli, Silvia, Benatti, Stefania, Debbia, Giulia, Rossi, Davide, Zucchini, Patrizia, Potenza, Leonardo, Luppi, Mario, Gaidano, Gianluca, Deaglio, Silvia, Marasca, Roberto
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685728/
https://ncbi.nlm.nih.gov/pubmed/29163807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21341
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