Ibrutinib modifies the function of monocyte/macrophage population in chronic lymphocytic leukemia

In lymphoid organs, nurse-like cells (NLCs) show properties of tumor-associated macrophages, playing a crucial role in chronic lymphocytic leukemia (CLL) cell survival. Ibrutinib, a potent inhibitor of Bruton's tyrosine kinase (BTK), is able to counteract pro-survival signals in CLL cells. Sinc...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Fiorcari, Stefania, Maffei, Rossana, Audrito, Valentina, Martinelli, Silvia, Hacken, Elisa ten, Zucchini, Patrizia, Grisendi, Giulia, Potenza, Leonardo, Luppi, Mario, Burger, Jan A., Deaglio, Silvia, Marasca, Roberto
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323207/
https://ncbi.nlm.nih.gov/pubmed/27602755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11782
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