Increased cFLIP expression in thymic epithelial tumors blocks autophagy via NF-κB signalling

The anti-apoptotic cellular FLICE-like inhibitory protein cFLIP plays a pivotal role in normal tissues homoeostasis and the development of many tumors, but its role in normal thymus (NT), thymomas and thymic carcinomas (TC) is largely unknown. Expression, regulation and function of cFLIP were analyz...

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Vydáno v:Oncotarget
Hlavní autoři: Belharazem, Djeda, Grass, Albert, Paul, Cornelia, Vitacolonna, Mario, Schalke, Berthold, Rieker, Ralf J., Körner, Daniel, Jungebluth, Philipp, Simon-Keller, Katja, Hohenberger, Peter, Roessner, Eric M., Wiebe, Karsten, Gräter, Thomas, Kyriss, Thomas, Ott, German, Geserick, Peter, Leverkus, Martin, Ströbel, Philipp, Marx, Alexander
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685693/
https://ncbi.nlm.nih.gov/pubmed/29163772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15929
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