HLA-DRB1*07:01–HLA-DQA1*02:01–HLA-DQB1*02:02 haplotype is associated with a high risk of asparaginase hypersensitivity in acute lymphoblastic leukemia

Hypersensitivity reactions are the most frequent dose-limiting adverse reactions to Escherichia coli-derived asparaginase in pediatric acute lymphoblastic leukemia (ALL) patients. The aim of the present study was to identify associations between sequence-based Human Leukocyte Antigen Class II region...

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Publicado en:Haematologica
Autores principales: Kutszegi, Nóra, Yang, Xiaoqing, Gézsi, András, Schermann, Géza, Erdélyi, Dániel J., Semsei, Ágnes F., Gábor, Krisztina M., Sági, Judit C., Kovács, Gábor T., Falus, András, Zhang, Hongyun, Szalai, Csaba
Formato: Artigo
Lenguaje:Inglês
Publicado: Ferrata Storti Foundation 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685222/
https://ncbi.nlm.nih.gov/pubmed/28596278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2017.168211
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