Blastocyst Formation Rate and Transgene Expression are Associated with Gene Insertion into Safe and Non-Safe Harbors in the Cattle Genome

Integration target site is the most important factor in successful production of transgenic animals. However, stable expression of transgene without disturbing the function of the host genome depends on promoter methylation, transgene copy number and transcriptional activity in integration regions....

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Vydáno v:Sci Rep
Hlavní autoři: Ghahfarokhi, Milad Khorramian, Dormiani, Kianoush, Mohammadi, Ali, Jafarpour, Farnoosh, Nasr-Esfahani, Mohammad Hossein
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684190/
https://ncbi.nlm.nih.gov/pubmed/29133827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15648-3
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