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Modularly Constructed Synthetic Granzyme B Molecule Enables Interrogation of Intracellular Proteases for Targeted Cytotoxicity

Targeted therapies promise to increase the safety and efficacy of treatments against diseases ranging from cancer to viral infections. However, the vast majority of targeted therapeutics relies on the recognition of extracellular biomarkers, which are rarely restricted to diseased cells and are thus...

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Detalhes bibliográficos
Publicado no:ACS Synth Biol
Main Authors: Ho, Patrick, Ede, Christopher, Chen, Yvonne Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5683712/
https://ncbi.nlm.nih.gov/pubmed/28510446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssynbio.6b00392
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