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Structure Optimization of Aloperine Derivatives as HIV-1 Entry Inhibitors
[Image: see text] As a step toward developing novel anti-HIV agents, we have identified a class of quinolizidines, including aloperine, that inhibit HIV at 1–5 μM by blocking viral entry. In this study, we have optimized the structure of aloperine and derived compounds with markedly improved activit...
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| Publicado no: | ACS Med Chem Lett |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2017
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5683702/ https://ncbi.nlm.nih.gov/pubmed/29152054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00376 |
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