YAP-Dependent AXL Overexpression Mediates Resistance to EGFR Inhibitors in NSCLC

The Yes-associated protein (YAP) is a transcriptional co-activator upregulating genes that promote cell growth and inhibit apoptosis. The main dysregulation of the Hippo pathway in tumors is due to YAP overexpression, promoting epithelial to mesenchymal transition, cell transformation, and increased...

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Detaylı Bibliyografya
Yayımlandı:Neoplasia
Asıl Yazarlar: Ghiso, Elena, Migliore, Cristina, Ciciriello, Vito, Morando, Elena, Petrelli, Annalisa, Corso, Simona, De Luca, Emmanuele, Gatti, Gaia, Volante, Marco, Giordano, Silvia
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Neoplasia Press 2017
Konular:
Original article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5683041/
https://ncbi.nlm.nih.gov/pubmed/29136529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2017.10.003
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