YAP-Dependent AXL Overexpression Mediates Resistance to EGFR Inhibitors in NSCLC

The Yes-associated protein (YAP) is a transcriptional co-activator upregulating genes that promote cell growth and inhibit apoptosis. The main dysregulation of the Hippo pathway in tumors is due to YAP overexpression, promoting epithelial to mesenchymal transition, cell transformation, and increased...

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Bibliografiske detaljer
Udgivet i:Neoplasia
Main Authors: Ghiso, Elena, Migliore, Cristina, Ciciriello, Vito, Morando, Elena, Petrelli, Annalisa, Corso, Simona, De Luca, Emmanuele, Gatti, Gaia, Volante, Marco, Giordano, Silvia
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press 2017
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Original article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5683041/
https://ncbi.nlm.nih.gov/pubmed/29136529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2017.10.003
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