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YAP-Dependent AXL Overexpression Mediates Resistance to EGFR Inhibitors in NSCLC
The Yes-associated protein (YAP) is a transcriptional co-activator upregulating genes that promote cell growth and inhibit apoptosis. The main dysregulation of the Hippo pathway in tumors is due to YAP overexpression, promoting epithelial to mesenchymal transition, cell transformation, and increased...
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| Pubblicato in: | Neoplasia |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Neoplasia Press
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5683041/ https://ncbi.nlm.nih.gov/pubmed/29136529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2017.10.003 |
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