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Translesion synthesis DNA polymerases promote error-free replication through the minor-groove DNA adduct 3-deaza-3-methyladenine

N3-Methyladenine (3-MeA) is formed in DNA by reaction with S-adenosylmethionine, the reactive methyl donor, and by reaction with alkylating agents. 3-MeA protrudes into the DNA minor groove and strongly blocks synthesis by replicative DNA polymerases (Pols). However, the mechanisms for replicating t...

詳細記述

保存先:
書誌詳細
出版年:J Biol Chem
主要な著者: Yoon, Jung-Hoon, Roy Choudhury, Jayati, Park, Jeseong, Prakash, Satya, Prakash, Louise
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5682974/
https://ncbi.nlm.nih.gov/pubmed/28939775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.808659
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