MicroRNA-145 attenuates TNF-α-driven cartilage matrix degradation in osteoarthritis via direct suppression of MKK4

Cartilage dyshomeostasis contributes to osteoarthritis (OA) pathogenesis, and tumor necrosis factor (TNF)-α has critical role in this process by driving inflammatory cascades and cartilage degradation. However, the negative regulation of TNF-α-mediated signaling remains undefined. Here we demonstrat...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Hu, Guoli, Zhao, Xiaoying, Wang, Chuandong, Geng, Yiyun, Zhao, Jingyu, Xu, Jiajia, Zuo, Bin, Zhao, Chen, Wang, Chenglong, Zhang, Xiaoling
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5682684/
https://ncbi.nlm.nih.gov/pubmed/29072705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.522
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