HSF4 regulates lens fiber cell differentiation by activating p53 and its downstream regulators

Cataract refers to opacities of the lens that impede the passage of light. Mutations in heat shock transcription factor 4 (HSF4) have been associated with cataract; however, the mechanisms regarding how mutations in HSF4 cause cataract are still obscure. In this study, we generated an hsf4 knockout...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Gao, Meng, Huang, Yuwen, Wang, Ling, Huang, Mi, Liu, Fei, Liao, Shengjie, Yu, Shanshan, Lu, Zhaojing, Han, Shanshan, Hu, Xuebin, Qu, Zhen, Liu, Xiliang, Assefa Yimer, Tinsae, Yang, Lifang, Tang, Zhaohui, Li, David Wan-Cheng, Liu, Mugen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5682647/
https://ncbi.nlm.nih.gov/pubmed/28981088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.478
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